The gut microbiome has an impact on weight loss.

 

 

 

 

According to new research, the gut microbiome has an impact on persons' ability to lose weight. The findings were published in the American Society for Microbiology's open-access journal mSystems this week.

"Your gut microbiota may support or hinder weight reduction, and this opens up the prospect of altering the gut microbiome to influence weight loss," said Christian Diener, Ph.D., lead study author and research scientist at the Institute for Systems Biology in Seattle, Washington.

Dr. Diener and colleagues centered their research on a large cohort of people who were enrolled in a lifestyle intervention programme. This solution combined a commercial behavioural coaching programme with recommendations from a dietician and nurse coach, rather than a specific diet or exercise programme. The researchers looked at 48 people who lost more than 1% of their body weight per month for six to twelve months and 57 people who didn't lose any weight but had a stable body mass index (BMI) over that time. Metagenomics, or the analysis of genetic material collected from blood and stool samples, was used by the researchers. In the two groups, the individuals looked at blood metabolites, blood proteins, clinical labs, dietary questionnaires, and gut bacteria.

The researchers discovered 31 baseline stool metagenomic functional characteristics that were linked with weight loss responses after controlling for age, sex, and baseline BMI. Complex polysaccharide and protein breakdown genes, stress-response genes, respiration-related genes, cell wall synthesis genes, and gut bacterial replication rates were among the genes identified. The ability of the gut microbiome to break down starches was shown to be increased in persons who did not lose weight, which was a significant discovery. Another important result was that persons who dropped more weight had more genes that help bacteria grow quicker, proliferate, replicate, and assemble cell walls.

"We knew the composition of bacteria in the gut was different in obese people than in non-obese people before this study," Dr. Diener said. "But now we've found that there's a different set of genes expressed in the bacteria in our gut that also reacts to weight loss strategies." "The gut microbiome plays a key role in determining whether or not a weight loss regimen is successful. The elements that determine whether or not you will lose weight as a result of a lifestyle change are not the same as those that determine whether or not you will lose weight as a result of a lifestyle change."

The mix of microorganisms in your stomach can be altered by changing your food, according to research. If someone's gut bacterial gene composition imposes resistance to weight loss, according to Dr. Diener, you might be able to change their diet to move to a composition that will help them lose weight.

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